Immune Aspects of Fibromyalgia

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A study of fibromyalgia using full genome microarray gene expression analysis “showed upregulation of 12 genes (>1.8-fold change, p < .05) in the FMS sample. Differentially expressed genes were related to B-cell development, primary immunodeficiency signaling, and mitotic roles of polo-like kinase. CENPK and HSP90AA1 were the most differentially expressed genes (p < .01).” They concluded: “Activity of interrelated pathways related to immune response, and homeostasis appears to be relevant to the experience of FMS.” (Comparing Genomic Profiles of Women With and Without Fibromyalgia. Lukkahatai N1, Walitt B2, Espina A3, Wang D3, Saligan LN4. Biol Res Nurs. 2015 Jul;17(4):373-83. 26.)

The subject of antibody abnormalities in fibromyalgia has been reviewed by et al. This field is a work in progress. It has not reached the point whereby there are standard recommendations to test for these antibodies in fibromyalgia patients. Furthermore, not all studies confirm all the findings. Clinicians are still trying to determine how to integrate these findings into clinical practice. This is especially true when the occasional fibromyalgia patient presents with serious and unusual illness. Biology and therapy of fibromyalgia. Evidence-based biomarkers for fibromyalgia syndrome. Dina Dadabhoy, Leslie J Crofford, Michael Spaeth, I Jon Russell, Daniel J Clauw. Arthritis Res Ther. 2008; 10(4): 211.

The following antibody types have been found to be increased in various studies of fibromyalgia:

antiserotonin antibody

antiganglioside antibody

antiphospholipid antibody

antithromboplastin antibody antipolymer antibody

anti-68/48 kDa

anti-45 kDa

The situation is still a little unclear and not all findings have been replicated.