Fibromyalgia, Hyperexcitable C-fiber Nociceptors in

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A microneurography study of peripheral C nociceptor function in fibromyalgia found abnormal behaviour of silent nociceptors in 76.6% patients. This included spontaneous activity in 31% of their silent nociceptor. They also found: “Sensitization to mechanical stimulation was found in 24.2% of silent nociceptors in fibromyalgia”. Furthermore there was: “Abnormally high slowing of conduction velocity when first stimulated at 0.25Hz was more common in fibromyalgia.” The authors summarized their findings by stating: “We show for the first time that the majority of fibromyalgia patients have abnormal C nociceptors. Many silent nociceptors exhibit hyperexcitability resembling that in small-fiber neuropathy, but high activity-dependent slowing of conduction velocity is more common in fibromyalgia patients, and may constitute a distinguishing feature.” (Hyperexcitable C nociceptors in fibromyalgia. Serra J1, Collado A, Solà R, Antonelli F, Torres X, Salgueiro M, Quiles C, Bostock H. Ann Neurol. 2014 Feb;75(2):196-208.)

[Author’s comment: Paresthesias are exceedingly common in fibromyalgia. This seems to be helping to understand this. More study is needed to clarify why the C-fibers are not functioning properly.]