Amplified Musculoskeletal Pain Syndrome (AMPS)

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(Summarized from the ACR.)


  • Increasing pain over time
  • Allodynia (a painful sensation in response to non-painful touch)
  • Disproportional physical disability, and the absence of other causes

Common additional symptoms[edit]

  • Debilitating fatigue
  • Disrupted or non-restorative sleep and a variety of neuropsychiatric problems, including ‘brain fog’, anxiety
  • Depressive symptoms

Possible associated symptoms[edit]

  • Overt autonomic signs, such as elevated heart rate or blood pressure (local or generalized over the whole body)
  • Skin colour or temperature changes (local or generalized over the whole body)


  • Localized AMPS (two or fewer affected body regions in the absence of autonomic changes)
  • Complex regional pain syndrome, type 1 (localized AMPS plus autonomic changes)
  • Diffuse AMPS (three or more affected body regions)

Pain category[edit]

This is a form of non-inflammatory musculoskeletal pain.

Propensity in childhood[edit]

Other names you might hear are: juvenile fibromyalgia syndrome, chronic musculoskeletal pain (CMP), It is most common during childhood and adolescence especially pre-adolescent and adolescent girls from the ages of 11.5 to 15 years. It is believed nonexistent in children under 4 years of age.

Further information[edit]

For further details on causes and treatment see: